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See  Risk Factors beginning on page 11 for a discussion of information that should be considered in connection with an investment in our securities./Per Share and Accompanying Purchase Warrant<Per Pre-Funded Warrant and Accompanying Purchase WarrantTotalPublic offering price(1))Underwriting discounts and commissions(2)Proceeds to us, before expensesЯ%ј400,260 shares of common stock issuable upon the exercise of stock options outstanding as of April 30, 2019 at a weighted-average exercise price of $101.82 per share;b17,063 shares of common stock reserved for issuance upon settlement of restricted stock units;Њ72,304 shares of common stock issuable upon the exercise of warrants outstanding as of April 30, 2019 at a weighted-average exercise price of $3.82 per share; and17,142,000 shares of common stock issuable upon the exercise of the purchase warrants being offered in this prospectus;`188,658 shares of common stock reserved for the future awards under our 2015 Incentive Plan.STATEMENTS OF OPERATIONSYear Ended October 31,Six Months Ended April 30,201820172019RevenueOperating expenses:%Research and development expenses'General and administrative expensesTotal operating expenses!(Loss) income from operationsOther income (expense):Interest income, net7Net changes in fair value of derivative liabilities-3Loss on shares issued in settlement of warrantsOther expense5Net (loss) income before benefit for income taxes Income tax expense (benefit)Net (loss) income&Net (loss) income per common shareBasicDiluted8Weighted average number of common shares outstandingAs of April 30, 2019ActualAs Adjusted(2)(in thousands) Consolidated Balance Sheet Data:Cash and cash equivalentsWorking capital(1) Total assets1Loan payable, net of current portion and discountTotal stockholders equityJApril 30, 2019 (unaudited) (in thousands, except share and par value data) Pro Forma&Cash, cash equivalents and investmentsStockholders equity:•Preferred stock, $0.001 par value per share, 5,000,000 shares authorized; 0 shares issued and outstanding actual, pro forma and pro forma as adjusted БCommon stock, $0.001 par value per share, 170,000,000 shares authorized; 8,020,370 shares issued and outstanding, actual, 17,220,370 shares issued and outstanding, pro formaAdditional paid-in capitalAccumulated deficitTotal capitalizationІ72,304 shares of common stock issuable upon the exercise of warrants outstanding as of April 30, 2019 at a weighted-average exercise price of $3.82 per share;17,142,000 shares of common stock issuable upon the exercise of the purchase warrants being offered in this prospectus; andName of Beneficial Owner,Total # of Shares Beneficially OwnedPercentage of OwnershipKenneth Berlin (1)*%David Sidransky (2)Roni Appel (3)Richard Berman (4)Samir Khleif (5)James Patton (6)Andres Gutierrez (7)-%Molly Henderson (8)Robert Petit (9).All Directors and Officers as a Group (10)2.16% UNDERWRITING UnderwritersNumber of Shares!Number of Pre-Funded WarrantsNumber of Purchase Warrants#A.G.P./Alliance Global Partners"Discount, Commissions and Expenses0Per Share and Accompanying Purchase WarrantGPer Pre- Funded Warrant and Accompanying Purchase WarrantWithout Over- AllotmentWith Over- AllotmentPublic offering price+Underwriting discounts and commissions (7%) Proceeds, before expenses, to usItalyрto Italian qualified investors, as defined in Article 100 of Decree no. 58 by reference to Article 34-ter of CONSOB Regulation no. 11971 of 14 May 1999 ( Regulation no. 1197l ) as amended ( Qualified Investors ); and­in other circumstances that are exempt from the rules on public offer pursuant to Article 100 of Decree No. 58 and Article 34-ter of Regulation No. 11971 as amended.1INCORPORATION OF CERTAIN INFORMATION BY REFERENCEoour Annual Report on Form 10-K for the year ended October 31, 2018, filed with the SEC on January 11, 2019;Вour Quarterly Reports on Form 10-Q for the quarters ended January 31, 2019, filed with the SEC on March 12, 2019, and April 30, 2019, filed with the SEC on June 10, 2019;_our Definitive Proxy Statement on Schedule 14A, filed with the SEC on January 11, 2019; and&our Current Reports on Form 8-K filed with the SEC on December 13, 2018, January 23, 2019, February 7, 2019, February 22, 2019, March 1, 2019, March 14, 2019, March 15, 2019, March 29, 2019, April 5, 2019, April 15, 2019, May 13, 2019, May 15, 2019, June 27, 2019 and July 15, 2019.џ bL cc Л Ь d-Cыт6?_€%,С*+‚ƒ„&ffffffц?'ffffffц?(ш?)ш?Ё"d,, Ж` Ж`р? 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